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KMID : 1123920230370040061
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Korean Journal of Oriental Physiology and Pathology
2023 Volume.37 No. 4 p.61 ~ p.67
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A Review on Hwangjenaegyeong Somun Sagijosindaelon Chapter One Based on Melatonin Metabolism
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Cho Jung-Hyo
Jeon Ah-Young
Park Sang-Soo
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Abstract
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This paper aims to reinterpret an ancient Chinese medical book called "The Yellow Emperor’s Classic of Medicine" (Hwangjenaegyeong in Korean) from the perspective of melatonin and antioxidant action. In the main body of the paper, we will first explain the changes in circadian rhythms according to the seasons through the first chapter of Somun "Sagijosindaelon". Spring, summer, autumn, and winter are introduced, and their relevance to disease is discussed. Next, the role of the suprachiasmatic nucleus in regulating circadian rhythms in mammals and the synchronization of peripheral clocks with seasonal changes is described. The relationship between light stimulation and melatonin synthesis is then addressed, noting that melatonin synthesis is normally inhibited in the presence of light and produced in the dark. However, recent studies have shown that there are more forms of melatonin that are produced in the presence of sunlight. Finally, it emphasizes the effect of light exposure on the biological clock and the importance of melatonin produced in the mitochondria, suggesting that we should focus on increasing melatonin levels. This paper reinterprets "The Yellow Emperor’s Classic of Medicine" from the perspective of melatonin metabolism and provides insights into healthy living.
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KEYWORD
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Melatonin, Metabolism, Hwangjenaegyeong, Mitochondria, Seasons
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